Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system’s ability to fight melanoma in mice. The agents, dubbed s-DAB-IL-2 and s-DAB-IL-2(V6A), comprise a regulatory protein called human interleukin-2 fused to chemically modified portions of diphtheria toxin. In a mouse model of melanoma, the two agents, when given together, depleted so-called T regulatory cells that infiltrate tumors and hinder the immune system’s ability to…
Read MoreAuthor: Tom Patriot
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Miranda Kerr & Evan Spiegel Are Expecting Their Second Baby Together
Congratulations are most definitely in order—Miranda Kerr is expecting her second baby with her husband, Snapchat co-founder Evan Spiegel. Us Weekly confirmed the happy news about Kerr’s third pregnancy, with the couple’s rep telling People, “Miranda, Evan, Flynn and Hart are looking forward to welcoming the newest member to their family.” Kerr gave birth to her first baby with Spiegel, a son called Hart, in May 2018. She also shares a son—eight-year-old Flynn—with ex-husband Orlando Bloom. Kerr and Spiegel announced their engagement in July 2016, after meeting at a Louis Vuitton dinner in 2014, per E!…
Read MoreChildhood trauma may affect brain structure, predisposing adults to recurring major depressive disorder
Early life trauma may affect the structure of the brain in a way that makes clinical depression more likely to be severe and recurrent, according to a two-year observational study of 110 patients published in The Lancet Psychiatry journal. Previous studies have suggested an association between maltreatment and altered brain structure, while others have identified an association between maltreatment and major depressive disorder. This is the first study that directly establishes a link between maltreatment experiences, brain structural alterations and clinical course of depression. It is also the first to shed light…
Read MoreGeneric weight-loss drug may be safe and effective for long-term treatment
An inexpensive weight-loss drug approved 60 years ago for only short-term use also may be safe and effective for longer-term treatment, according to a study conducted by researchers at Wake Forest Baptist Health and the Patient Outcomes Research to Advance Learning (PORTAL) network. The study is published in today’s issue of the journal Obesity. The drug, phentermine, is currently FDA-approved for use of up to three months. “Although diet and exercise are critical components of any weight-loss program, up to half of patients don’t have long-term success with lifestyle changes alone,”…
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